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Anhydroicaritin Standard (≥98% HPLC) | CAS 118525-40-9 | Natural Osteoblast Activator
Anhydroicaritin 98% (CAS 118525-40-9) is a high-purity, prenylated flavonoid naturally found in Epimedium species. This potent bioactive compound demonstrates significant effects in stimulating bone formation and inhibiting bone resorption, making it a key research target for osteoporosis therapeutics. It also exhibits notable neuroprotective properties, protecting neurons through anti-inflammatory and antioxidant mechanisms.
Product Name :
AnhydroicaritinCAS No. :
118525-40-9Appearance :
Pale yellow crystalline powderSpecification :
80%-98%CAS: 118525-40-9
Molecular Formula: C??H??O?
Molecular Weight: 368.38 g/mol
Appearance: Pale yellow crystalline powder
Dual-Target Osteoprotective & Anticancer Agent
≥98% Purity (HPLC-ELSD validated)
Bone Formation: Stimulates osteoblast differentiation via BMP-2/Smad pathway (3.1× vs control)
Antimetastatic: Inhibits breast cancer cell migration (IC??: 7.2 μM in MDA-MB-231)
Musculoskeletal Health
Osteoporosis Reversal: 10 mg/kg/day ↑ bone density by 32% in OVX rats
Cartilage Protection: Reduces MMP-13 expression by 76% at 5 μM
Oncological Activity
ERα Degradation: Downregulates estrogen receptor alpha (EC??: 0.8 μM)
Angiogenesis Blockade: Suppresses VEGF secretion by 68% at 10 μM
Neuroprotective Effects
Aβ Aggregation Inhibition: 50% reduction at 25 μM (Alzheimer's models)
Dopaminergic Protection: ↑ TH+ neurons by 41% in MPTP-induced Parkinsonism
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-UV, λmax 270 nm) |
| Source | Epimedium brevicornum (organic cultivated) |
| Melting Point | 223-225°C |
| Solubility | DMSO (80 mg/mL), Ethanol (25 mg/mL) |
| Storage | -20°C in argon-filled vials (24 months) |
| Key Impurities | Icaritin ≤0.5%, Desmethylicaritin ≤0.3% |
Pharmaceutical Development
Osteoporosis Formulations: 10-50 mg capsules with vitamin D? synergy
Breast Cancer Therapy: ERα-targeting nanoparticle conjugates (Phase I trial)
Nutraceuticals
Bone Health Supplements: 15 mg/day + calcium (↑ BMD 12% in postmenopausal women)
Cognitive Support: 5% lipid-based delivery systems for blood-brain barrier penetration
Cosmeceuticals
Anti-Aging Serums: 0.5% nanoemulsions ↓ collagen fragmentation by 55%
Hair Growth Activators: 0.1% solutions ↑ anagen phase duration 2.3×
Patented Extraction
CO? Supercritical → Ethanol Recrystallization
Yield: 92.4% at ≥98% purity
Solvent residue: <5 ppm
Crystal Engineering
Monoclinic P2?/c form (XRD-verified)
Bulk density: 0.48 g/cm³
Flowability: Carr index 14
Global Compliance
Dossiers for:
FDA Osteoporosis IND
EU Traditional Herbal Registration
China NMPA Class 1 New Drug
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 10g | Amber glass vial + PTFE cap | 24 months |
| 25g | Aluminum pouch + desiccant | 24 months |
| 100g | HDPE jar with nitrogen purge | 24 months |
| 500g | Vacuum-sealed steel can | 24 months* |
| 1kg | UN fiber drum + poly liner | 24 months* |
|
*Storage at -20°C, O? <0.1%
|
Identity Confirmation:
UV: λmax 270 nm (MeOH)
MS: m/z 369.13 [M+H]?
Purity Method:
HPLC (C18, 30°C)
Mobile phase: MeOH/H?O (75:25)
RT: 8.7±0.2 min
Stability Data:
24 months @ -20°C: Purity 98.2±0.5%
Shipping:
Cryogenic transport (-70°C) for all orders
Global delivery via DHL/FedEx Priority (1-5 days)
Documentation:
Batch-specific COA with HPLC/LC-MS
cGMP manufacturing records
ICH stability reports
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