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Rhein 98% is a high-purity anthraquinone derivative extracted from Rheum palmatum (rhubarb), celebrated for its bioactive properties in traditional herbal medicine. Verified by HPLC to contain ≥98% purity, this premium extract supports detoxification pathways, modulates inflammatory responses, and promotes metabolic balance by targeting key cellular signaling networks.
Product Name :
RheinCAS No. :
478-43-3Appearance :
Yellow to orange crystalline powderSpecification :
98%Rhein (Rhubarb Extract) 98%
CAS: 478-43-3
Molecular Formula: C??H?O?
Molecular Weight: 284.22
Appearance: Yellow to orange crystalline powder
Multi-Concentration Flexibility
≥98% Pure: Pharmaceutical/Nutraceutical Grade (HPLC-verified)
1%-50% Blends: Cost-effective solutions for functional foods and cosmeceuticals
Anti-Tumor & Chemoprevention:
Inhibits proliferation of melanoma (76% suppression in murine models), breast cancer, and hepatocellular carcinoma by modulating NF-κB and STAT3 pathways, inducing apoptosis via mitochondrial disruption.
Antioxidant & Anti-Inflammatory:
Reduces oxidative stress by scavenging ROS and suppresses COX-2, lowering systemic inflammation and LDL oxidation.
Metabolic & Renal Health:
Reverses insulin resistance, lowers serum triglycerides by 18–32% in diabetic models, and protects against diabetic nephropathy via glucose transporter- inhibition.
Antibacterial Activity:
Effective against Staphylococcus aureus and P. acnes (MIC: 1.5–25 mg/mL) by inhibiting bacterial DNA synthesis.
| Parameter | Detail |
|---|---|
| Purity Range | 1%, 5%, 10%, 98%+ (HPLC) |
| Source | Rheum palmatum L. roots |
| Extraction Solvent | Ethanol (food-grade, GRAS) |
| Melting Point | 321–322°C (sublimes) |
| Storage | 2–8°C, sealed, avoid light (24-month stability) |
| Heavy Metals | ≤10 ppm (USP/EP compliant) |
| Solubility | Soluble in alkaline solutions, pyridine; insoluble in water 16 |
?? Pharmaceuticals:
Cancer Adjuvants: Synergizes with chemotherapy in liver and colorectal cancer regimens.
Diabetic Nephropathy Therapy: Improves renal function in Type 1/2 diabetes models.Cosmeceuticals:
?? Cosmeceuticals:
Anti-Acne Formulations: Antibacterial action against P. acnes.
Anti-Aging Serums: Neutralizes UV-induced free radicals and reduces photoaging.
?? Energy Technology:
DSSC Co-Sensitizers: Enhances solar cell efficiency (7.83% vs. baseline 7.13%) by reducing electron recombination in TiO? anodes.
?? Advanced Extraction & Purification:
Ultrasound-Assisted Extraction: 92% yield vs. 60% conventional methods.
Resin Chromatography: Combines HPD-300 macroporous resin with preparative HPLC for >98% purity.
?? Bioactivity Optimization:
Ethanol-based process preserves thermolabile anthraquinone antioxidants, avoiding degradation to inactive metabolites .
?? Certified Quality & Compliance:
ISO 9001/Kosher/Halal certified. Full dossier support (COA, MSDS, Stability Data). Meets FDA GRAS, EU Novel Food, and APAC safety standards.
| Cargo Weight | Packaging Method | Shipping | Lead Time |
|---|---|---|---|
| 1–25 kg | Double PP bags + cardboard drum | DHL/FedEx | 7 days |
| 25–500 kg | Sealed foil bags in fiber drums | Air freight | 7–10 days |
| >500 kg | Customized palletized drums | Sea freight | 20–55 days |
How to verify Rhein authenticity?
Free samples (20g) with batch-specific COA (HPLC/UV verification at λmax 432nm).
Can I request custom derivatives?
Yes—OEM services for:
Alkylated Rhein (e.g., C6/C8 chains for DSSC co-sensitizers).
Mitochondria-Targeted Probes: Triphenylphosphonium conjugates for cancer theranostics.
Critical storage notes?
Degrades ≤15%/month at 25°C; strict 2–8°C storage required to maintain potency.
?? Sustainable Sourcing: Rheum palmatum from GAP-certified farms (Xinjiang, China).
?? End-to-End Customization:
Extraction ratios (1% to 98%), enteric coatings, private labeling.
Derivatives for targeted drug delivery (e.g., liver cancer mitochondria probes).
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