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Cycloastragenol-6-O-β-D-glucoside (CAS: 86764-12-7) is a high-activity triterpenoid saponin derived from Astragalus membranaceus, extensively utilized in pharmaceutical research and natural product development. With molecular formula C??H??O?? (MW: 652.87), this compound exhibits reported bioactivities including diuretic and analgesic effects.
Product Name :
Cycloastragenol-6-O-β-D-glucosideCAS No. :
86764-12-7Appearance :
Fine white powderSpecification :
98%? Dual-Action Bioactivity: Telomere Protection + Anti-Inflammation
Telomerase Activation: Enhances telomerase activity by 40–60% in human fibroblasts, delaying cellular senescence and supporting anti-aging therapies.
Systemic Defense: Potent ROS scavenger (IC?? = 3.2 μM in DPPH assay), reducing oxidative stress in cardiovascular and neuronal tissues.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-ELSD) |
| Appearance | White to off-white crystalline powder |
| Solubility | Slightly soluble in water; Freely soluble in DMSO, methanol, ethanol |
| Storage | 2–8°C in airtight container, protected from light |
| Shelf Life | 24 months (with stability studies) |
| Key Physicochemical Properties | • Density: 1.32±0.1 g/cm³ (20°C) 1 • pKa: 12.91±0.70 7 |
Anti-Aging & Skin Regeneration
Mechanism: Upregulates TERT gene expression, increasing collagen synthesis by 30% in human dermal fibroblasts.
Efficacy: Reduces wrinkle depth by 22% in 12-week clinical trials (1% topical formulation).
Cardiometabolic Protection
Lipid Regulation: Lowers serum LDL-C by 18% and triglycerides by 15% in hyperlipidemic models.
Endothelial Support: Inhibits TNF-α-induced inflammation in vascular cells (IC?? = 5.8 μM).
Immunomodulation
T-Cell Activation: Boosts CD4+/CD8+ lymphocyte proliferation by 35%, validated in murine models.
| Sector | Formulation Examples |
|---|---|
| Pharmaceuticals | - Telomere-supportive capsules (10–50 mg/day) - Adjuvant therapy for age-related fibrosis |
| Cosmeceuticals | - Anti-aging serums (0.5–2% w/w) - Wound-healing creams with collagen boosters |
| Nutraceuticals | - Longevity supplements (e.g., blends with NAD+ boosters) - Cardioprotective functional beverages |
?? Advanced Purification Technology
Chromatography Process: Multi-step HPLC purification (>99.5% peak area), removing astragaloside IV impurities.
Residual Control: Solvents <50 ppm (ICH Q3C compliant), heavy metals <5 ppm .
?? Sustainable & Traceable Sourcing
Botanical Origin: Astragalus membranaceus roots (cultivated in GAP-certified Chinese farms, batch-to-batch traceability).
Extraction Method: Ethanol/water gradient extraction, preserving glycoside integrity.
?? Certifications & Compliance
ISO 9001.
Full documentation: COA, SDS, Stability Data.
| Quantity | Primary Packaging | Shipping | Delivery Time |
|---|---|---|---|
| 20mg–1g | Amber glass vial + desiccant | FedEx Priority | 3–5 days |
| 1g–100g | Vacuum-sealed foil bag | DHL Express | 5–8 days |
| >100g | Food-grade HDPE drum | Sea freight | 15–30 days |
Q: Is batch-specific COA provided?
A: Yes, each shipment includes a validated COA with HPLC chromatogram, residual solvents, and heavy metals report.
Q: Can custom concentrations be formulated?
A: We offer OEM services for:
Water-soluble complexes (cyclodextrin encapsulation)
Oil-based emulsions for topical use
Sterile-filtered solutions for injectables (R&D grade)
Q: Minimum order quantity (MOQ)?
A: 20mg for R&D (≥98% purity); 100g for commercial batches.
Q: Stability in final products?
A: Compatible with pH 4–8 matrices; 24-month stability data available upon request.
R&D Collaboration: Access to preclinical data on telomerase activation and toxicity profiles (LD?? >2000 mg/kg in rats).
Supply Chain Security: Dual sourcing from Chengdu (China) and EU partners, ensuring uninterrupted supply.
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Cycloastragenol-6-O-β-D-glucoside (CAS: 86764-12-7) is a high-activity triterpenoid saponin derived from Astragalus membranaceus, extensively utilized in pharmaceutical research and natural product development. With molecular formula C??H??O?? (MW: 652.87), this compound exhibits reported bioactivities including diuretic and analgesic effects.
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