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Gentiopicroside 98% (CAS: 20831-76-9) is a premium bioactive extracted from Gentiana scabra roots, clinically proven to disrupt skin inflammation at the molecular level. This HPLC-validated crystalline powder (≥98% purity, λmax 270 nm) targets TNF-α/NF-κB pathways, delivering.
Product Name :
GentiopicrosideCAS No. :
20831-76-9Appearance :
Off-white crystalline powderSpecification :
80%-98%Molecular Formula: C??H??O?
Molecular Weight: 356.33 g/mol
Appearance: Off-white crystalline powder (hygroscopic)
Key Cosmetic Action: Potent Anti-Inflammatory & Skin-Barrier Modulator
≥98% Purity (HPLC-validated, λmax 270 nm)
Redness Reducer: Inhibits TNF-α/NF-κB pathway (↓88% IL-6 at 50 μM)
Barrier Repair: Upregulates filaggrin & claudin-1 expression (3.2× vs. control)
Anti-Pigmentation: Suppresses MITF and tyrosinase via IL-1β downregulation
Rosacea/Redness: 0.5% serum reduces erythema index by 52% in 4 weeks (clinical, n=32)
Itch Relief: Blocks histamine H1/H4 receptors (IC??: 18.7 μM)
Collagen Defense: Inhibits MMP-1 (81%), MMP-3 (76%), and MMP-9 (69%) at 100 μg/mL
Wrinkle Reduction: 1% nanoemulsion ↓ wrinkle depth by 41% in UVB-exposed skin (8-week study)
Melanin Synthesis: Disrupts α-MSH/MC1R signaling (↓43% melanin vs. arbutin)
Post-Inflammatory Marks: 2% cream fades UV-induced spots by 37% in Fitzpatrick IV skin
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-PDA, Cosmetics Europe compliant) |
| Solubility | Water (20 mg/mL), glycerin (80 mg/mL), propylene glycol (120 mg/mL) |
| pH Stability | 4.0–8.0 (maintains >95% activity) |
| Storage | 2–8°C in opaque containers (24-month stability) |
| Key Impurities | Loganic acid ≤0.8%, swertiamarin ≤0.5% |
| Certifications | ISO 9001, COSMOS Organic, Vegan |
Redness Relief: 0.2–0.5% with 1% bisabolol (synergy index 1.6)
Brightening Boost: 1% + 2% niacinamide (↑ glutathione synthesis 2.3×)
Barrier Creams: 0.5–1% in ceramide-based systems (↑ TEWL recovery 59%)
Anti-Aging: 1% in squalane emulsion + 0.3% retinol (↓ irritation by 78%)
UV Damage Repair: 0.3% in aloe vera gel (↓ sunburn cells by 65%)
Anti-Pollution: 0.2% with ectoin (↑ Nrf2 activation 2.1×)
Green Extraction Tech
Ultrasonic-assisted extraction → D101 resin purification (yield: 93.5%, solvent-free)
Enhanced Bioavailability
β-cyclodextrin inclusion complexes (↑ skin penetration 3.8× vs. free form)
Stability Solutions
Photostable with 0.05% tocopheryl acetate + 1% octinoxate (96% retention after 3J/cm² UVA)
| Quantity | Format | Shelf Life |
|---|---|---|
| 100 g | Pharma HDPE jar + nitrogen | 24 months |
| 500 g | Vacuum-sealed aluminum bag | 24 months |
| 1 kg | UV-block PET drum (2–8°C, RH<30%) | 24 months |
Dermal Safety: Non-irritating (HET-CAM test), non-comedogenic (0.1)
Allergen-Free: Gluten-free, non-GMO, no synthetic preservatives
Heavy Metals: As <0.1 ppm, Pb <0.2 ppm (ISO 21392)
Q: How to incorporate into water-based serums?
A: Pre-dissolve in glycerin (1:4 ratio) → add to aqueous phase at <40°C.
Q: Efficacy in acidic formulations (AHA/BHA)?
A: Stable at pH 3.5–5.5; boosts AHA efficacy (↑ collagen I by 33% vs. AHA alone).
Q: Synergy with brightening actives?
A: Pair with tranexamic acid (↓ melanin 58%) or α-arbutin (↑ tyrosinase inhibition 1.9×).
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Read More
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