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Premium Eupatilin (CAS 22368-21-4) - High-Purity Lipophilic Flavonoid for Research & Pharma
Eupatilin (CAS 22368-21-4) is a high-purity lipophilic flavonoid isolated from Artemisia species (e.g., mugwort leaves). As a potent PPARα agonist, it exhibits significant anti-inflammatory, antioxidant, and anti-apoptotic activities, making it ideal for pharmaceutical and biomedical research.
Product Name :
EupatilinCAS No. :
22368-21-4Appearance :
Yellow crystalline powderSpecification :
98%CAS: 22368-21-4
Molecular Formula: C??H??O?
Molecular Weight: 344.32 g/mol
Appearance: Yellow crystalline powder
Dual-Mode Gastroprotective & Anti-Allergic Flavonoid
≥98% Purity: Pharmaceutical grade (HPLC-PDA/MS-validated)
Mucosal Healing Activator: Accelerates gastric ulcer repair via COX-2/PGE? pathway modulation (in vivo).
Mast Cell Stabilizer: Inhibits histamine release (IC??: 8.2 μM) in IgE-mediated allergic models.
Gastric Ulcer Healing:
Oral 10 mg/kg/day reduces ulcer index by 74% in ethanol-induced gastritis models via TGF-β1 upregulation.
Anti-Allergic Efficacy:
Blocks NF-κB translocation, reducing TNF-α by 89% at 20 μM in RBL-2H3 mast cells.
Antioxidant Synergy:
Scavenges ROS (EC??: 15.3 μM) and enhances glutathione synthesis in hepatic models.
Colitis Remission:
0.5% enema formulation decreases mucosal damage by 68% in DSS-induced colitis via IL-6/STAT3 suppression.
| Parameter | Detail |
|---|---|
| Purity Range | ≥98% (HPLC-UV, λmax 340 nm) |
| Source | Artemisia asiatica aerial parts |
| Melting Point | 228–231°C |
| Solubility | DMSO, ethanol; insoluble in H?O |
| Storage | -20°C in desiccated vials (36-month stability) |
| Key Impurities | Jaceosidin ≤0.8% (HPLC-controlled) |
GI Therapeutics:
20–50 mg enteric-coated tablets for chronic gastritis (phase III trials).
Allergy Management:
2% nasal sprays inhibit seasonal rhinitis symptoms (histamine ↓63% in clinical pilot).
Functional Foods:
10 mg/serving in probiotic synbiotics for gut barrier integrity.
Dermatological Formulations:
0.5–1.5% creams mitigate atopic dermatitis pruritus (IL-31 ↓57%).
Green Extraction Tech:
Supercritical CO? extraction achieves 96% yield with zero organic solvent residues.
Nano-Delivery Systems:
PLGA nanoparticles enhance oral bioavailability 4.1× (AUC?–??: 58.7 μg·h/mL vs. 14.3 μg·h/mL free).
Global Compliance:
Prepared dossiers for US FDA OTC Monograph, EMA Traditional Herbal Registration, and JP XVI.
| Cargo Weight | Packaging Method | Shipping | Lead Time |
|---|---|---|---|
| 1–500 mg | Argon-sealed amber vials | Cold FedEx | 3 days |
| 500 mg–5 kg | Vacuum aluminum pouches | Air freight | 7–10 days |
| >5 kg | Humidity-controlled drums | Sea freight | 25–40 days |
Q: How to verify mast cell stabilization?
A: Batch-specific in vitro RBL-2H3 degranulation assay reports provided.
Q: Solubility for IV formulations?
A: Use HP-β-cyclodextrin inclusion (solubility ↑ to 9.8 mg/mL in saline).
Q: Photostability in creams?
A: Stable >90% under UV light for 12 months with 0.1% α-tocopherol.
Sustainable Cultivation:
Custom Modifications:
Eupatilin Sodium Salt: Water-soluble for infusions
Liposomal Eupatilin: Targeted delivery for IBD therapeutics
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