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5-Hydroxy-7-Methoxyflavone (CAS: 520-28-5) is a naturally occurring flavonoid with ≥98% purity verified by HPLC. Known for its anti-inflammatory, antioxidant, and neuroprotective properties, it is widely used in nutraceuticals, functional foods, and cosmetic formulations.
Purity: ≥98% (HPLC validated)
Appearance: Light yellow crystalline to off-white powder
Key Functions: NF-κB inhibition, ROS scavenging, cognitive and cardiovascular support
Applications: Dietary supplements, functional beverages, anti-aging skincare products
Packaging: 100 g / 1 kg / 5 kg with long-term stability
Nanjing Spring & Autumn Biological Engineering Co., Ltd. provides high-quality flavonoid ingredients with global supply capacity, strict quality control, and professional technical support.
Product Name :
5-Hydroxy-7-MethoxyflavoneCAS No. :
520-28-5Appearance :
Light yellow crystalline to off-white powderSpecification :
98%
| Parameter | Detail |
|---|---|
| Name | 5-Hydroxy-7-Methoxyflavone |
| CAS Number | 520-28-5 |
| Molecular Formula | C??H??O? |
| Molecular Weight | 268.27 g/mol |
| Appearance | Yellow to off-white crystalline powder |
| Purity | ≥98% (HPLC-DAD, C18 reverse phase) |
| Melting Point | 183–185°C |
| Solubility | DMSO (60 mg/mL), ethanol (20 mg/mL), lipophilic |
| Storage | -20°C, protected from light, stable for 36 months |
| Key Impurities | ≤1.0% related flavones (HPLC controlled) |
| Certifications | ISO 9001 |
Anti-Inflammatory Benefits
Inhibits COX-2 and NF-κB signaling pathways.
Reduces pro-inflammatory cytokines (TNF-α ↓68%, IL-6 ↓59%).
Antioxidant & Cellular Protection
Scavenges reactive oxygen species (ROS ↓65% at 20 μM).
Enhances Nrf2/HO-1 pathway, boosting antioxidant enzyme activity.
Cognitive & Cardiovascular Support
Neuroprotective against oxidative stress and amyloid-induced toxicity.
Improves endothelial function and lipid metabolism.
Cosmetic & Anti-Aging Potential
Reduces glycation end-products formation in skin fibroblasts.
Provides UV-protection and anti-oxidative skin care benefits.
Nutraceuticals: Functional supplements for metabolic and cognitive health.
Functional Foods: Fortified beverages, health oils, antioxidant-rich foods.
Cosmeceuticals: Anti-aging serums, UV-protection creams, anti-glycation skincare.
Research Use: Flavonoid-based studies in anti-inflammatory and neuroprotection pathways.
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 100 g | Double aluminized bags + argon | 24 months |
| 1 kg | Pharma-grade PET jars | 24 months |
| 5 kg | Vacuum-sealed stainless steel | 24 months |
Storage Condition: -20°C, oxygen <0.1%, light-protected.
Stability: Verified under ICH Q1A guidelines.
Q: Is assay data available for purity verification?
A: Yes, HPLC chromatograms and COA are provided with each batch.
Q: How to improve solubility for formulation?
A: Use nanoemulsion systems, phospholipid complexes, or oil carriers.
Q: Can it be applied in skincare formulations?
A: Yes, validated stable incorporation at 0.05–0.2% in emulsions and serums.
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