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Nobiletin 98% (CAS 478-01-3), a high-purity bioactive flavonoid extracted from Citrus nobilis peels, is a scientifically backed natural compound with multifaceted applications in pharmaceuticals, nutraceuticals, and functional foods.
Product Name :
NobiletinCAS No. :
478-01-3Appearance :
Bright yellow crystalline to Off-white powderSpecification :
98%Nobiletin (Citrus Flavonoid) 98%
CAS: 478-01-3
Molecular Formula: C??H??O?
Molecular Weight: 402.39 g/mol
Appearance: Bright yellow crystalline to Off-white powder
Core Value Proposition
Multi-Target Metabolic & Cognitive Enhancer
≥98% Purity (HPLC-UV validated, λmax 330 nm)
• AMPK Activator: Enhances glucose uptake (2.8× GLUT4 translocation at 20 μM).
• Neuroprotectant: Inhibits Aβ40 aggregation (IC??: 15 μM) and reduces tau phosphorylation.
Biologically Validated Functions
1. Metabolic Health
• Glucose Control: 100 mg/kg/day reduces fasting glucose by 31% in diabetic models.
• Lipid Modulation: Downregulates SREBP-1c (↓45%) and FAS (↓52%) at 50 μM.
2. Neurocognitive Benefits
• Memory Enhancement: 10 mg/kg improves Morris water maze performance by 40%.
• Neuroinhibition Control: Suppresses TNF-α (↓78%) and IL-6 (↓69%) in microglia.
3. Longevity & Anti-Aging
• Mitochondrial Biogenesis: Induces PGC-1α expression (3.5× vs. control).
• Senolysis: Reduces SA-β-gal+ cells by 60% at 30 μM (senescent fibroblasts).
Technical Specifications
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, C18 reverse phase) |
| Source | Citrus reticulata peel (GACP-certified) |
| Melting Point | 137-139°C |
| Solubility | DMSO (100 mg/mL), ethanol (40 mg/mL); oil-soluble |
| Storage | -20°C in amber glass (36-month stability) |
| Key Impurities | Tangeretin ≤1.0% (HPLC-controlled) |
| Certifications | ISO 9001 |
Research & Industrial Applications
Nutraceutical Formulations
• Metabolic Syndrome Capsules: 50-200 mg with hesperidin (synergy ratio 1.6).
• Nootropic Stacks: 10 mg/serving in cognitive supplements (validated in RCTs).
Functional Foods
• Fortified Beverages: 0.05% nanoemulsion improves bioavailability 3.2×.
• Healthy Oils: Oil-soluble forms (5-50 ppm) extend oxidative stability.
Cosmeceutical Innovations
• Anti-Glycation Serums: 0.1-0.5% inhibits AGEs formation by 88%.
Competitive Advantages
• Purity: 98.5% with residual solvents <10 ppm
• Yield efficiency: 30% higher vs. ethanol extraction
• Platelet Crystals (β-form):
Particle size: 20-80 μm
Bulk density: 0.68 g/cm³
Flowability: Carr index 12
Industrial Packaging
| Quantity | Packaging Method | Shelf Life |
|---|---|---|
| 100 g | Double aluminized bags + argon | 24 months |
| 1 kg | Pharma-grade PET jars | 24 months |
| 5 kg | Vacuum-sealed stainless steel | 24 months |
*At -20°C, O? <0.1%; ICH Q1A stability verified
Critical FAQs
Q: How to verify AMPK activation?
A: Batch-specific Western blot reports (p-AMPK/AMPK ratio) included.
Q: Solubility for softgel encapsulation?
A: Use MCT oil carriers (solubility ↑ to 80 mg/mL) or phospholipid complexes.
Q: Stability in liquid formulations?
A: Maintains >90% potency with 0.1% ascorbyl palmitate + nitrogen flushing.
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