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Premium 20(S)-Protopanaxadiol (CAS：30636-90-9) | ≥98% HPLC Purity | Ginsenoside Metabolite Reference Standard
20(S)-Protopanaxadiol (CAS 30636-90-9) is a high-purity ginsenoside aglycone metabolite, rigorously validated by HPLC to ensure ≥98% quality. As the core bioactive component of Panax ginseng, it serves as an essential reference standard for pharmaceutical research, nutraceutical development, and metabolic studies. This compound demonstrates significant potential in modulating anti-inflammatory, neuroprotective, and anticancer pathways.
Product Name :
20(S)-ProtopanaxadiolCAS No. :
30636-90-9Appearance :
White to off-white crystalline powderSpecification :
40%、90%&98%Molecular Formula: C??H??O? | Molecular Weight: 460.74
Appearance: White to off-white crystalline powder
Source: Roots of Panax ginseng C. A. Mey. (Asian ginseng), sustainably cultivated in China.
? Pharma-Grade Purity & Bioactivity
Exclusively ≥98% Pure: Rigorously verified by HPLC-DAD/ELSD, NMR, and MS, with lot-specific Certificates of Analysis (COA) ensuring batch-to-batch consistency.
Bioactivity Guaranteed: Confirmed apoptosis induction via Akt inhibition and P-glycoprotein suppression, validated in multidrug-resistant cancer cell lines (IC??: 23–24 μg/mL in Int-407 and Caco-2 cells).
? Clinically Validated Benefits
Suppresses Tumor Growth: Inhibits proliferation in liver, lung, and melanoma cancers by blocking cyclin D1 expression and inducing G1-phase cell cycle arrest.
Overcomes Chemo-Resistance: Enhances efficacy of chemotherapy agents (e.g., CTX) while reducing toxicity, acting as a potent adjuvant in pancreatic/breast cancer therapy.
Neuroprotective & Anti-Inflammatory: Modulates GABA? and serotonergic receptors to attenuate stress-induced inflammation (e.g., reduces IL-6 and corticosterone levels).
| Parameter | Detail |
|---|---|
| Purity | 40%、90%、98% (HPLC-ELSD/DAD) |
| Identification | NMR, Mass Spectrometry |
| Storage | 2–8°C, sealed, inert atmosphere, protected from light |
| Shelf Life | 24 months* |
| Solubility | DMSO (85 mg/mL), ethanol (31 mg/mL); insoluble in water |
| Melting Point | 197–200°C |
| Packaging | 20 mg–50 kg (vacuum-sealed vials or GMP drums) |
?? Oncology & Pharmacology
Chemotherapy Adjuvant: Reverses multidrug resistance in myeloid leukemia and colon adenocarcinoma by downregulating P-gp efflux pumps .
Metastasis Inhibition: Reduces cancer cell migration by suppressing N-cadherin/integrin β1 and focal adhesion kinase phosphorylation.
?? Neuroprotection & Immunology
Anti-Anxiety Effects: Potentiates GABA? receptors to mitigate stress-induced behavioral deficits (validated in elevated plus-maze tests).
Immune Modulation: Enhances NK cell activity and CD4/CD8 ratios in tumor microenvironment.
| Advantage | Detail |
|---|---|
| Bioactivity Proof | Lot-specific apoptosis induction data included |
| Ethical Sourcing | Traceable to cultivated Panax ginseng (China) |
| Global Compliance | ISO 9001, USP/EP heavy metals ≤10 ppm, Kosher-certified |
| Cost Efficiency | Fermentation-derived production (vs. wild extraction) cuts cost by 80% |
| Weight | Packing Method | Transport |
|---|---|---|
| 20 mg–1 kg | Amber glass vials + desiccant + dry ice | DHL/FedEx (3–7 days) |
| 1 kg–25 kg | Sealed buckets with temperature loggers | By Air (5–10 days) |
| >25 kg | GMP drums (-20°C monitored) | By Sea (15–45 days) |
Q: How to verify anti-tumor efficacy?
→ Free 10 mg samples provided with COA + in vitro apoptosis assay data (e.g., U251-MG cell line).
Q: Solubility limitations for in vivo studies?
→ Cyclodextrin-complexed analogs available for enhanced aqueous delivery (OEM inquiries accepted).
Q: Stability during long-term storage?
→ Stability-tested for 24 months at 2–8°C; nitrogen-backfilled packaging prevents oxidation.
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Read More
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