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Phorbol 98%: Reliable Diterpene Standard for Pharmacology and Toxicology Research
Phorbol 98% (CAS:17673-25-5) is a high-purity diterpenoid isolated from Croton tiglium seeds, serving as the foundational compound for tumor-promoting phorbol esters like PMA. With ≥98% HPLC-verified purity and characteristic needle crystals, it enables critical research in PKC-mediated carcinogenesis, apoptosis resistance, and multi-drug resistance reversal.
Product Name :
PhorbolCAS No. :
17673-25-5Appearance :
White to off-white crystalline powderSpecification :
98%CAS: 17673-25-5
Molecular Formula: C??H??O?
Molecular Weight: 364.43 g/mol
Appearance: White to off-white crystalline powder
High-Purity Tumor Promoter & PKC Pathway Activator
≥98% Purity (HPLC-UV validated, λmax 234 nm)
Mechanistic Research Tool: Serves as the core structure for bioactive esters (e.g., PMA) in PKC-dependent carcinogenesis and immunology studies.
Natural Source Integrity: Sourced from Croton tiglium seeds, preserving native diterpenoid activity.
1. Tumor Promotion Research
Acts as a progenitor of tumor-promoting esters (e.g., PMA) in two-stage carcinogenesis models, enabling mechanistic studies of PKC-mediated cell proliferation.
Metabolic Activation: Liver microsomes convert phorbol to active esters in vivo, mimicking endogenous tumor promotion pathways.
2. Pharmacological Synergy
Enhances cytotoxicity of chemotherapeutics (e.g., doxorubicin) in multidrug-resistant cancer lines via PKCα modulation.
| Parameter | Detail |
|---|---|
| Purity | ≥98% (HPLC-DAD, C18 column) |
| Source | Croton tiglium seeds (Xinjiang origin, pesticide-free) |
| Melting Point | 249–251°C (decomposition) |
| Solubility | DMSO (30 mg/mL), ethanol (soluble); water-soluble (1 mg/mL) |
| Storage | -20°C in desiccated amber vials (24-month stability) |
| Key Impurities | Jaceosidin ≤0.2% (HPLC-controlled) |
| Hazard Classification | T+ (Toxic) - R26/27/28 |
Oncology & Toxicology
Tumor initiation studies: Metabolic precursor for synthesizing PMA (CAS 16561-29-8), used in DMBA-initiated skin carcinogenesis models.
Apoptosis resistance research: Modulates PKCε to inhibit anoikis in metastatic cell lines.
Natural Product Chemistry
Reference standard for quantifying phorbol esters in Croton extracts via alkaline hydrolysis (HPLC conditions: Diamonsil C18 column, acetonitrile/water gradient).
1. Sustainable Purification Technology
D101 macroporous resin chromatography: Ethanol/water gradient elution achieves 91.08% purity with 62.16% recovery, reducing organic solvent use by 40% vs. silica gel methods.
2. Batch-Specific Bioactivity Data
Free alkaline hydrolysis protocol with yield validation reports (included with ≥25 mg orders).
3. Global Compliance Ready
Full analytical dossiers support FDA ICH Q3C and EU GMP registration (residual solvent limits: methanol <3000 ppm).
| Quantity | Packaging | Storage | Stability |
|---|---|---|---|
| 1 mg | Argon-sealed glass vial | -20°C | 24 months |
| 5 mg | Desiccated amber vial | -20°C | 24 months |
| 25 mg | Pharma-grade aluminum can | -20°C (dry) | 24 months* |
| 100 mg | Nitrogen-flushed drum | -20°C (dry) | 24months* |
*With desiccant; reconstituted solutions stable 3 months at -20°C in DMSO.
Toxicity: LD?? (oral, rat) = 1 mg/kg; use fume hood + nitrile gloves17.
Waste Disposal: Inactivate with 10% sodium hypochlorite → neutralize to pH 7 → incinerate.
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