2-Bromo-5-Hydroxybenzoic Acid (CAS 58380-11-3): A High-Purity Brominated Aromatic Intermediate for Research and Industrial R&D

January 22, 2026

Introduction: From Simple Aromatic Structure to Versatile Chemical Building Block

In modern chemical research and industrial development, well-defined aromatic intermediates play a critical role in enabling precise synthesis and controlled molecular design.
2-Bromo-5-Hydroxybenzoic Acid, a brominated benzoic acid derivative, has gained increasing attention as a versatile building block in organic synthesis, pharmaceutical research, and specialty chemical development.

Unlike complex mixtures or undefined reaction intermediates, 2-Bromo-5-Hydroxybenzoic Acid (CAS 58380-11-3) is a single, structurally well-characterized compound designed to meet the growing demand for high-purity, reproducible, and traceable raw materials in research and industrial R&D environments.

At Nanjing Spring & Autumn Biological Engineering Co., Ltd., we supply 2-Bromo-5-Hydroxybenzoic Acid primarily for laboratory research, process development, and intermediate synthesis, supporting global B2B customers with consistent quality and complete analytical documentation.

What Is 2-Bromo-5-Hydroxybenzoic Acid?

2-Bromo-5-Hydroxybenzoic Acid is a brominated aromatic acid featuring both a bromine substituent and a hydroxyl group on the benzene ring.
This dual functionalization provides multiple reactive sites, making the compound particularly useful in substitution, coupling, and derivatization reactions.

Key characteristics of 2-Bromo-5-Hydroxybenzoic Acid include:

• Clearly defined chemical structure

• High purity and batch consistency

• Good stability under recommended storage conditions

• Suitability for controlled synthetic and mechanistic studies

These attributes make it a reliable intermediate for applications where structural clarity and reproducibility are essential.

Why Choose a Defined Aromatic Intermediate Instead of Mixed Reaction Systems?

In chemical synthesis and early-stage development, the use of well-defined intermediates can significantly improve process control and experimental reliability.

Compared with in-situ generated or mixed intermediates, 2-Bromo-5-Hydroxybenzoic Acid offers several advantages:

1. Improved Reproducibility

Using a purified compound helps reduce variability across experiments, supporting more consistent results in both research and scale-up studies.

2. Clear Structural and Dosage Control

As a single compound, it allows precise control over reaction inputs, which is critical for pathway optimization and structure–activity exploration.

3. Broad Compatibility in Organic Synthesis

The presence of both bromine and hydroxyl groups enables flexible downstream modification, supporting diverse synthetic strategies.

Applications in Research and Industrial R&D

2-Bromo-5-Hydroxybenzoic Acid is supplied primarily for non-finished-product applications, including:

• Organic synthesis and reaction development

• Pharmaceutical and fine chemical intermediate research

• Specialty chemical and material science R&D

• Reference compound use in analytical and method development

• Process optimization and scale-up studies

Note: This product is supplied for research and industrial R&D use only and is not marketed as a finished consumer product.

Quality Control and Documentation

At Nanjing Spring & Autumn Biological Engineering Co., Ltd., 2-Bromo-5-Hydroxybenzoic Acid is produced and supplied under standardized quality control procedures to ensure consistency and reliability.

Available documentation includes:

• Certificate of Analysis (COA)

• Purity and identification data

• Chromatographic analysis (HPLC, where applicable)

• Batch traceability information

This documentation package supports global B2B sourcing, technical evaluation, and regulatory review where required.

Supply Capabilities

• Product Name: 2-Bromo-5-Hydroxybenzoic Acid

• CAS Number: 58380-11-3

• Chemical Type: Brominated aromatic acid

• Application: Research & industrial R&D

• Supply Mode: B2B only

Custom specifications, packaging options, and technical support are available upon request based on project needs.

Conclusion

As chemical research and industrial development continue to emphasize precision, reproducibility, and traceability, well-defined intermediates such as 2-Bromo-5-Hydroxybenzoic Acid are becoming increasingly important.

By offering a high-purity, structurally clear, and consistently supplied aromatic intermediate, 2-Bromo-5-Hydroxybenzoic Acid provides researchers and developers with a reliable foundation for efficient synthesis and innovation—supporting both exploratory research and applied R&D projects.

For technical details, samples, or project-based inquiries, please contact
Nanjing Spring & Autumn Biological Engineering Co., Ltd.